Microsatellite DNA instability in benign lung diseases
نویسندگان
چکیده
منابع مشابه
Microsatellite DNA instability and COPD exacerbations.
Increased frequency of microsatellite DNA instability (MSI) has been detected in the sputum of chronic obstructive pulmonary disease (COPD) patients. The aim of the present study was to investigate the relationship between MSI in sputum cells and exacerbation frequency, which is an important parameter in the clinical course of the disease. Induced sputum samples and peripheral blood obtained fr...
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Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring instability in the microsatellite sequences of both the coding and non-coding regions of the genome. Mutated mismatch repair genes result in the expansion or contr...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2006
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2005.05.015